Sheet 00 · Cover

Building the frontier of software. Engineering the future of medicine.

I am a computer science student at Colorado School of Mines, with a minor in Quantum Engineering. I work on computational protein design and on how AI agents behave when they work together. I graduate in May 2027 and plan to start a PhD in computational and systems biology that fall.

Studying
B.S. Computer Science, Mines '27
Working on
Protein design · AI agents
Also
NCAA D-II pole vault
Tony Peonio, smiling, in a light blue checked shirt outdoors
Tony PeonioGolden, Colorado

Sheet 01 · Blueprints

It started with houses.

Growing up in Kalama, a small town in southwest Washington, I spent most of my free time helping with my family's construction business. I worked through every step of homes being built from the ground up and watched architects' blueprints turn into real structures. That is where I picked up an obsession with understanding complex systems, and it carried over into chemistry sets, electronics kits, and eventually code.

A protein, it turns out, is also a structure built from a plan. It is just .

SCALE 1 : 1,000,000,000 HOUSE → PROTEIN SHEET 01 · DETAIL
Top7 (PDB 1QYS): a new fold designed from scratch with Rosetta, drawn from its real coordinates.

Sheet 02 · Mines

Computer science, with some quantum on the side.

I came to Mines to study computer science because I wanted to connect the digital world to the physical one. I added a minor in Quantum Engineering, and by my second year I was taking graduate courses in quantum information alongside my undergraduate classes.

I am finishing my degree in three years and have kept a 4.0 along the way.

When I am not at a keyboard, I am usually on the track: I pole vault for the Mines track and field team. It is a good reminder that plans only matter if you commit to the jump. I also lead the Society of Quantum Engineers as president, serve on the Student-Athlete Advisory Committee, and help run a campus wellness club as treasurer.

Sheet 03 · The pivot

From quantum materials to biology.

My first research was in the Honors VIPER quantum materials course, searching computationally for new quantum materials. I enjoyed it, but I decided materials weren't the application I wanted to pursue. I wanted to write algorithms that produce something that could physically heal people. So I joined the Bioinformatics Club and started teaching myself structural biology.

The fastest way to learn was to enter the 2026 Mines Protein Engineering Competition, which ran for four months. The goal I chose was a protein that binds nitrogenase without shutting it down, as a first step toward cheaper nitrogen fixation.

  1. Problem. I did not have access to a computing cluster, so everything ran on a PC I built myself.
  2. Wall. Targets larger than 2,000 residues spilled out of my GPU's memory and slowed my runs to a crawl.
  3. Workaround. I came up with a process I called serine painting: crop away the chains far from the interface I was targeting, then replace the exposed hydrophobic residues on the cut face with serine, so the designs would not stick to an artifact of the cut. That brought targets down to around 600 residues.
  4. Result. Using RFdiffusion, ProteinMPNN, LocalColabFold, and PyRosetta, I generated thousands of designs and used the data to find hotspots. After four months, I won the competition.

Afterward, I generalized those pipelines into a beginner-friendly protein engineering pipeline and published it as open source, so other computer scientists can get into protein design with less setup than I had. It is always a work in progress.

Sheet 04 · Summer 2026

Oregon × Rosetta Commons

One summer, two communities: a lab at the University of Oregon, and the Rosetta Commons network of protein design labs that ran the program.

University of Oregon · Eugene

Designing peptides in the Hosseinzadeh Lab

I spent the summer as a Rosetta Commons NSF REU researcher in Dr. Parisa Hosseinzadeh's lab, computationally designing cyclic peptides. I read through the literature, built design pipelines from scratch in Python, Bash, and RosettaScripts on the lab's computing cluster, and had candidates ready for wet-lab testing within five weeks.

My first designs had trouble reaching the binding pocket. Working around that problem ended up shaping the whole project, which is a pattern I keep running into.

The first designs are now being tested in the wet lab with collaborators, and I am still working with the lab remotely.

5 weeks to first candidates Still collaborating

Rosetta Commons · RosettaCon 2026

Presenting the work

At the end of the summer I gave a lightning talk and presented a poster at RosettaCon 2026.

Lightning talk + posterComputational design of FPR2-specific cyclic peptides for resolution of chronic inflammation

Earlier that year, at an APS conference, I felt like an outsider looking in. At RosettaCon, after months in the literature, I had long conversations at posters and over meals, and I finally felt like an equal in the scientific community.

Sheet 05 · Agents

What happens when AI agents work together?

Back at Mines, I reached out to Dr. Lincoln Carr and joined his group, where I study how communities of AI agents interact and what behaviors emerge when they do.

Protein design taught me what one model can do. This work is about what happens when many of them are connected, and it is a big part of why I am interested in AI safety and biosecurity research. The same tools that design proteins and coordinate agents deserve careful study.

Build log

The short version

The same story as a construction schedule. Dashed entries are planned, not finished.

  1. 2021 to 2024

    College courses in high school

    Took dual-enrollment classes at three Washington colleges while finishing high school in Kalama.

  2. Fall 2024

    Started at Colorado School of Mines

    Computer science, a Quantum Engineering minor, and the track and field team.

  3. Fall 2025

    First research

    Joined the Honors VIPER quantum materials course and the AMBER air-quality group, and started taking graduate-level courses in quantum information.

  4. Spring 2026

    Protein design and AI agents

    Won the Mines Protein Engineering Competition and joined Dr. Lincoln Carr's group to study multi-agent AI.

  5. Summer 2026

    Oregon and RosettaCon

    Rosetta Commons NSF REU in the Hosseinzadeh Lab, then a lightning talk and poster at RosettaCon 2026.

  6. Fall 2026

    Senior year

    Field session with Kirin Autonomy, still working with the Hosseinzadeh Lab, and getting ready to mentor first-generation students back home.

  7. May 2027

    Graduate from Mines

    Three years after starting.

  8. Fall 2027

    Start a PhD

    Computational and systems biology.

Parts list

Projects

A few things I have built, what problem each one was for, and what came out of it.

Python · RFdiffusion · ProteinMPNN Always a work in progress

Protein engineering pipeline for beginners

Getting started with protein design tools takes a lot of setup, especially coming from computer science.

Generalized my competition and research pipelines into an open-source starting point for newcomers.

View on GitHub →
Protein design · GPU memory

Serine painting

Targets over 2,000 residues did not fit in a home PC's GPU memory.

Cropped distant chains and capped the cut face with serine, bringing targets to about 600 residues.

Read the story →
Rosetta Commons NSF REU

FPR2-specific cyclic peptides

Designing cyclic peptides that act on one receptor and not its close relative.

Candidates in wet-lab testing; presented at RosettaCon 2026.

Read the story →
Mines × Kirin Autonomy In progress · Fall 2026

Adaptive chess AI

A chess neural network that estimates a player's skill from their decisions.

Adjusts the AI's difficulty in real time; built during my senior field session.

Kotlin · Python · AMBER group

Air-quality data apps

Participants in an air-quality study across Colorado needed secure access to their own data.

Built user-facing Kotlin and Python applications for the Mechanical Engineering AMBER group.

Honors VIPER

Quantum materials discovery

My first research project: computational discovery of new quantum materials.

Where I learned research, and where I learned I wanted to work on biology.

Sheet pending

More on the way

This parts list gets longer every semester.

Talks and presentations

  • RosettaCon 2026 Lightning talk and poster. "Computational design of FPR2-specific cyclic peptides for resolution of chronic inflammation"

Sheet 06 · Giving back

Sending the ladder back down.

I only found my way into research because people answered my emails. I try to return the favor.

Starting soon

Rural first-gen mentoring. I am working with my old high school's college counselor to mentor first-generation students interested in STEM or athletics, and I hope to bring in other Mines students to reach more rural schools.

Student Advisory Board for Quantum Programs

As an invited member of this multi-university board, I analyzed departmental data on undergraduates in graduate courses. Part of my experience was presented in the program evaluators' talk at the NSF NRT conference, and the board's mentorship proposals are now before faculty.

Planned, not done yet

A Rural Bio-Initiative for Kalama: science seminars and shared Colab notebooks on how medicines are designed and tested, so people at home can look at the data themselves.

Sheet 07 · What comes next

Predicting the signal, not just the fit.

I graduate from Mines in May 2027 and plan to start a PhD in computational and systems biology in Fall 2027.

The question I want to work on: structure prediction can now tell us where a molecule binds a receptor, but not which signal that receptor sends afterward. I want to build models that connect binding to signaling for G protein-coupled receptors (GPCRs), so designers can select for the response they want rather than binding strength alone.

Coming from computer science, I also know what I cannot teach myself on a PC: designing wet-lab validation, formal structural biophysics, and the statistics to know when a prediction is real. That is what graduate school is for.

Long term, I want to be a professor who does research, mentors first-generation students, and makes science easier to access.

Sheet 08 · Contact

Say hello.

I am especially interested in cyclic peptide design and neurological pharmaceuticals, and in the long run I want to help build treatments for mental health diseases. If you work on any of that, or on protein design, multi-agent AI, AI safety, or biosecurity, I would be glad to hear from you. The same goes for first-generation students figuring out research.